Long Live the Lung
3:40 - 4:10 PM | ZINNER BREAKOUT ROOM
4:10 - 4:40 PM | Collaboratory in Shapiro Lounge

This is a Post Event Networking Session

The experts at the Lung Center are bringing the latest technological advances to Brigham and Women’s Hospital to expand options for lung transplant recipients, increase the number of organs available, and improve the viability of donor lungs.

About The Roundtable

The experts at the Lung Center are bringing the latest technological advances to Brigham and Women’s Hospital to expand options for lung transplant recipients, increase the number of organs available, and improve the viability of donor lungs. Ex Vivo Lung Perfusion (EVLP) is a tool that improves the quality of donor lungs and their condition for transplantation.

After a brief movie showing this cutting-edge technique in action, participants will engage in a conversation structured around the impact of EVLP in various fields, its predicted impact on research, and the incredible potential it could have on patient outcomes. This roundtable discussion will truly bridge the connection between an idea conceived in a lab and a tangible technological phenomenon that has the power to change the course of patients’ lives.

CHAIRS

Raphael Bueno, MD
Frederic G. Levin Distinguished Chair in Thoracic Surgery
Lung Cancer Research Chief, Division of Thoracic Surgery
Co-Director, Brigham and Women’s Lung Center
Professor, Harvard Medical School

Bruce D. Levy, MD
Parker B. Francis Professor of Medicine, Harvard Medical School
Chief, Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital

DISCUSSANTS

Steven P. Keller, MD, PhD
Instructor of Medicine; Medical Director of ECMO, Brigham and Women’s Hospital

Bruce D. Levy, MD
Parker B. Francis Professor of Medicine, Harvard Medical School
Chief, Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital

Antonio Coppolino, III, MD, MSc
Director of Ex Vivo Lung Perfusion, Brigham and Women’s Hospital
Instructor, Harvard Medical School
 

Hari Reddy Mallidi, MD
Executive Director, for ECMO, Heart & Vascular Center
Co-Director, Lung Transplant, ECMO and Lung Assist Devices, The Lung Center
 

PATIENT

Jason Crowell

Biographies

Raphael Bueno, MD

Dr. Raphael Bueno is the Chief of Thoracic Surgery and Fredric G. Levin Distinguished Chair in Thoracic Surgery and Lung Cancer Research at Brigham and Women’s Hospital and a Professor of Surgery at Harvard Medical School.

He completed his Bachelor’s degree in the Biochemical Sciences at Harvard College (1981) and medical education at Harvard Medical School (HMS) in the Health Sciences and Technology program (combined Massachusetts Institute of Technology and HMS). He subsequently trained in General Surgery at Brigham and Women’s Hospital and in Thoracic Surgery at Massachusetts General Hospital. He joined the Brigham and Women’s Hospital (BWH) Thoracic Faculty in 1996. Over the past 21 years, Dr. Bueno has developed robust clinical and research portfolios at BWH. Administratively, he previously held the posts of Associate Chief of Division of Thoracic Surgery, Chief of Lung Transplant Program and Program Director of the Cardiac and Thoracic Residency Program as well as the fellowship program. He was appointed Professor of Surgery at HMS in 2011 and Chief of Thoracic Surgery in 2014.

His clinical focus is the management of thoracic malignancies including mesothelioma, lung cancer and esophageal cancer. His main research interests center on the molecular events that lead to malignancy in mesothelioma and lung cancer. Specifically, Dr. Bueno focuses on developing biomarkers for diagnosis, prognosis and predicting therapy in malignant pleural Mesothelioma and lung cancer. His research also includes tumor sequencing of and identification of targetable pathways. He runs a molecular biology lab at the George W. Thorn Medical Research Building and has been funded for almost two decades by the NCI, DOD, foundations and industry grants. He also invented, patented and licensed several algorithms and medical devices for patient care. Dr. Bueno has also invented and continues to develop several novel surgical procedures.

Bruce Levy, MD

Dr. Levy is the Parker B. Francis Professor of Medicine at Harvard Medical School and Chief of the Pulmonary and Critical Care Medicine Division at Brigham and Women’s Hospital. Bruce received his MD from the University of Pennsylvania School of Medicine. He completed his internship and residency in Internal Medicine and his fellowship in Pulmonary and Critical Care Medicine at Brigham and Women’s Hospital. He was a post-doctoral fellow in the laboratory of Dr. Charles Serhan.

Research undertaken in the Levy laboratory focuses on the roles of endogenous counter-regulatory mediators in the lung. The lab’s mission is “to identify novel pathways and cellular targets that promote resolution of pulmonary inflammation, infection or injury and to determine roles for naturally-derived, specialized pro-resolving mediators in lung health and disease as well as their potential as templates for rational new drug design.

Dr. Levy’s clinical interests include severe asthma, cough, lung infection, bronchiectasis, chronic obstructive pulmonary disease and acute respiratory distress syndrome. His laboratory aims to identify new pathways to resolve pulmonary inflammation, infection or injury through the roles of endogenous counter-regulatory mediators in the lung, and his work has helped lead to over 10 patents awarded or pending. He has written more than 150 peer-reviewed publications, has received funding from the National Institutes of Health continuously since 1993, and currently serves as a standing member of the LCMI study section and as a section editor of the Journal of Immunology and associate editor for the New England Journal of Medicine‘s clinical problem-solving interactive case series.  He has been elected into the American Society for Clinical Investigation, the Association of American Physicians and the Interurban Clinical Club. He has also been active in the American Thoracic Society and currently serves as Chair of the Publication Policy Committee and member of the Board of Directors.

Antonio Coppolino, III, MD, MMSc

Dr. Coppolino is a graduate of the University of Pennsylvania in Philadelphia, PA and received his medical degree from George Washington University School of Medicine & Health Sciences in Washington, DC. He completed a residency in General Surgery at New York-Presbyterian Hospital/Weill Cornell Medical Center in New York, NY, followed by a residency in Thoracic Surgery at Brigham and Women’s Hospital in Boston, MA. Most recently, Dr. Coppolino completed a fellowship in Heart and Lung Transplantation and Mechanical Circulatory Support again at Brigham and Women’s Hospital. Dr. Coppolino also holds an MSc in Clinical and Translational Science from Weill Cornell Graduate School of Medical Sciences in New York, NY.

He is board certified in general surgery by the American Board of Surgery and in thoracic surgery by the American Board of Thoracic Surgery.

His research and clinical interests include thoracic surgical oncology, end stage heart and lung disease, mechanical circulatory support, lung and heart transplantation and Ex-vivo lung perfusion.

Stephen Keller, MD, PhD

Dr. Keller joined the Division of Pulmonary and Critical Care Medicine in July 2016 as an Instructor and currently attends on the lung transplant, cardiac surgical and medical intensive care units, and serves as Medical Director of the ECMO mechanical support service.  He joined the Brigham and Women’s Hospital from the University of Pittsburgh Medical Center where he was on faculty and attended on the cardiothoracic, trauma, and medical intensive care units.

He received his medical degree from Stanford University and completed residency training in internal medicine at the Massachusetts General Hospital prior to completing fellowship training in pulmonary and critical care medicine at Johns Hopkins Hospital and the National Institutes of Health.  Before pursuing a career in medicine, Dr. Keller received his undergraduate degree from Purdue University in electrical engineering and his master’s in semiconductor physics at Cambridge University where he studied as a Churchill Scholar.  He received his doctorate in medical engineering from the Massachusetts Institute of Technology where he was awarded the Department of Defense and National Science Foundation graduate fellowships.

Dr. Keller is affiliated faculty at the Harvard-MIT Biomedical Engineering Center where he conducts research on mechanical circulatory support, organ-device interactions, and extracorporeal organ perfusion.

Hari Mallidi, MD, FRCSC

Dr. Hari Mallidi, MD, FRCSC, is the Co-Director for Lung Transplant, ECMO and Lung Assist Devices within the Surgical Program in Heart and Lung Transplantation and Mechanical and Circulatory Support at the Brigham and Women’s Hospital. He is the Surgical Director of Right Heart Rescue and Pulmonary Thromboendarterectomy in the Collaborative Center for Pulmonary Heart Disease, Senior Surgeon in the Collaborative Center for Advanced Heart Disease, Executive Director for ECMO at the Brigham and Women’s Hospital.

Dr. Mallidi graduated with honors from the University of Toronto, Faculty of Medicine with a Doctor of Medicine degree in 1997. He subsequently completed a cardiac surgical residency in Toronto and is certified by the Royal College of Physicians and Surgeons of Canada in 2005.  After completing a Cardiothoracic Transplant and Mechanical Circulatory Support Device Fellowship at Stanford University, he remained on faculty as an Assistant Professor in Cardiothoracic Surgery.  He led the Stanford University Medical Center’s program in Ventricular Assist Devices.

In 2012, Dr. Mallidi was recruited to the Baylor College of Medicine and the Texas Heart Institute in Houston, TX, to build a robust heart-lung and lung transplant program.  He held the Lester and Sue Smith Chair in Surgery.  He was the BCM Director of Adult Heart Transplantation and Co-Director of the Advanced Heart Disease Center of Excellence.  He was also the Surgical Director of the Lung and Heart-Lung Transplantation Program at Baylor St. Luke’s Medical Center.  He was Director of the Center for Cardiac Support at the Texas Heart Institute.  In 2015, Dr. Mallidi joined the Brigham and Women’s Hospital.

His primary interests include lung, heart and heart-lung transplantation, mechanical circulatory support (VAD and ECMO), surgery for hypertrophic cardiomyopathy, pulmonary thromboendarterectomy for chronic thromboembolic pulmonary hypertension, valvular heart disease and complex cardiac surgery. Dr. Mallidi’s research interests are primarily focused on evaluating the outcomes of surgical procedures and the clinical effectiveness of surgical interventions within cardiothoracic transplantation and mechanical circulatory support.