Information Innovation: The Power of Precision Medicine

2PM – 3PM | Bornstein Amphitheatre
Future woman with cyber technology eye panel concept

About the Session

 

The idea of healthcare being as customized as your coffee order at Starbucks is not just wishful thinking any more. It is fast approaching reality with rapid advances in the ability to extract and analyze multiple layers of patient data from the molecular level to the ‘exposome’. Seemingly endless amounts of information are emerging about every patient, condition, procedure, and drug across multiple providers and organizations. Knowledge about the intricate functional interdependencies between the biological components of a disease is also on the rise.  This outpour of information is in turn guiding diagnostic, prognostic and therapeutic strategies that are tailored for each patient’s biological requirements.  This precision and network medicine approach is taking us beyond the age of traditional black and white clinical decision making to an era of precise disease prevention, prediction and treatment around specific individuals. This session is a panel discussion that will highlight how BWH is gearing up to become the world leader in precision and network medicine with examples of how this approach has transformed the care of BWH patients in recent times and what challenges lie ahead.

Speakers


MODERATOR:

  • Richard Maas, MD, PhD
    Chief, Division of Genetics & Professor of Medicine
    Dept. of Medicine, Brigham & Women’s Hospital and Harvard Medical School

 

PANELISTS:

  • Soumya Raychaudhuri, M.D., Ph.D.
    Associate Professor of Medicine
    Dept. of Medicine, Brigham & Women’s Hospital and Harvard Medical School
    “Towards integrating genomics and immunoprofiling for precision medicine in complex rheumatic diseases”

 

  • Lynn Bry, PhD
    Associate Professor of Pathology
    Dept. of Pathology, Brigham & Women’s Hospital and Harvard Medical School
    “Clinical and therapeutic applications of the microbiota.”

 

  • Calum Macrae, MD, PhD
    Chief, Division of Cardiovascular Medicine & Associate Professor of Medicine
    Dept. of Medicine, Brigham & Women’s Hospital and Harvard Medical School
    “Reinventing the bedside exam for precision medicine”

 

  • Martha Bulyk, PhD
    Professor of Medicine & Pathology
    Dept. of Medicine & Dept. of Pathology,  Brigham & Women’s Hospital and Harvard Medical School

 

bry

Lynn Bry, PhD
Associate Professor of Pathology
Dept. of Pathology, Brigham & Women’s Hospital and Harvard Medical School

Dr. Bry is an Associate Professor of Pathology at Harvard Medical School. She also is Director of the Center for Metagenomics at Brigham & Women’s Hospital. Dr. Bry’s research areas include immunology, host-commensal interactions and medical informatics. Her laboratory studies host responses against attaching and effacing pathogens such as Citrobacter rodentium and the enteropathogenic E. coli (EPEC), as well as the molecular basis of mucosal projection from colonization with commensals. She attends in the Center for Advanced Molecular Diagnostics at Brigham and Women’s Hospital. Her group also manages the Crimson prospective sample collection core and additional multi-institutional infrastructure that supports a NIH grant portfolio of more than $150 million.

martha

Martha Bulyk, PhD
Professor of Medicine & Pathology
Dept. of Medicine & Dept. of Pathology,  Brigham & Women’s Hospital and Harvard Medical School

Dr. Bulyk’s group is currently focused on studies of transcription factors and DNA regulatory elements, using a variety of experimental and computational approaches, including new technologies they have developed. Dr. Bulyk received dual undergraduate degrees in Biology and in Mathematics from MIT and her Ph.D. in Biophysics from Harvard University, where she worked in Dr. George Church’s group. She is also an Associate Member of the Broad Institute of MIT and Harvard, and an Associate Member of the Dana Farber Cancer Institute’s Center for Cancer Systems Biology. In 2005 Dr. Bulyk was named one of the TR35, MIT Technology Review’s annual competition to select the top 35 young innovators under the age of 35, and in 2007 she was named in Genome Technology’s annual selection of “Tomorrow’s PIs”. She has served on numerous grant review panels and journal editorial boards, and is a Member of Faculty of 1000. Dr. Bulyk has published over 90 scientific articles and book chapters, and has presented over 160 invited seminars.

calum

Calum Macrae, MD, PhD
Chief, Division of Cardiovascular Medicine & Associate Professor of Medicine
Dept. of Medicine, Brigham & Women’s Hospital and Harvard Medical School

Dr. MacRae is a cardiologist and geneticist whose clinical interests include investigating new phenotypes and how research findings—including genomics discoveries—can be systematically implemented into clinical care. His research focuses on the biology and genomics of cardiovascular disease, specifically the biological basis of different arrhythmia susceptibilities. He holds five patents, has authored over 160 peer-reviewed publications and received research funding from the National Institutes of Health’s National Human Genome Research Institute. He is an expert member of BWH’s Cardiovascular Genetics Program, which comprehensively evaluates, diagnoses and manages care for inherited cardiac disorder patients. He received his medical degree from University of Edinburgh College of Medicine. He completed two internal medicine residency programs: one at Wellcome Trust Centre for Neuroimaging in London and the other at BWH. He then completed a fellowship in cardiovascular disease at Massachusetts General Hospital.

maas

Richard Maas, MD, PhD
Chief, Division of Genetics & Professor of Medicine
Dept. of Medicine, Brigham & Women’s Hospital and Harvard Medical School

Work in the Maas Laboratory focuses in two areas, both of which revolve around the problem of how vertebrate organs form. The first research area, embodied in a large, new and highly interdisciplinary research Consortium approach called SysCODE, or Systems based-Consortium for Organ Design and Engineering, is aimed at organ regeneration.  The second and more long-standing research area involves mechanistic investigations into Pax and Hox genes, their respective gene networks, and the genetic control vertebrate eye, craniofacial, pancreatic and kidney development.

soumya

Soumya Raychaudhuri, M.D., Ph.D.
Associate Professor of Medicine, Harvard Medical School
Associate Member, Broad Institute
Professor in Genetics, University of Manchester
Foreign Adjunct Professor, Karolinska Institutet
Divisions of Genetics & Rheumatology, Department of Medicine, Brigham and Women’s Hospital

Dr. Soumya Raychaudhuri is an Associate Professor at Harvard Medical School and at Brigham and Women’s Hospital. He is also appointed as an Associate Member at the Broad Institute and a Professor in Genetics at the University of Manchester. He matriculated into the Stanford University NIH funded MST program in 1997 after completing degrees in mathematics and biophysics at the University at Buffalo. In 2004, he completed both his medical training and his doctoral training in biomedical informatics. After completing his clinical training in Internal Medicine, he joined the rheumatology fellowship training program in 2006, and concurrently completed his postdoctoral fellowship training under Mark Daly at the Broad Institute. Since starting his own group in 2010 at Harvard Medical School and Brigham and Women’s Hospital, his lab has focused on finding and fine-mapping disease alleles and understanding their significance in immune-mediated diseases. He has focused on multiple diseases including rheumatoid arthritis, type I diabetes, and tuberculosis infection. He has worked on fine-mapping HLA loci, devising integrative statistical genetics strategies to identify causal variation by taking advantage of large-scale epigenetic data, and integrating genetic data with functional genomics and data on human immunological phenotypes.