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Next-Gen Regen: The Future of Regenerative Medicine

1PM – 2PM | Brigham Building for Transformative Medicine

About the Session

 

There’s a growing buzz surrounding the field of regenerative medicine. Stem-cell therapies hold the potential to make what sounds like science fiction become reality: the re-growth of limbs, the cure of autoimmune diseases and more. But these kinds of advances could still be decades away, and in the meantime, unregulated and unproven stem-cell based therapies could pose dangers to those seeking treatment. In this session, regenerative medicine experts will talk about the problem of early arthritis, solutions currently in clinical trials, how these therapies evolved out of basic research into cartilage in a BWH laboratory more than a decade ago, and how current basic research into salamanders (join us to see a live one!) might contribute towards our understanding of therapies on the horizon. A BWH patient will be present to talk about his perspective as well.

Speakers


MODERATOR:

  • Mallika Marshall, MD
    Health Reporter, WBZ-TV & Physician, Massachusetts General Hospital

 

PANELISTS:

  • Andreas H. Gomoll, MD
    Department of Orthopedic Surgery, Brigham and Women’s Hospital
    Associate Professor of Orthopedic Surgery, Harvard Medical School

 

  • Gloria Matthews, DVM, Ph.D.
    Chief Medical Officer, Histogenics

 

  • Jessica L. Whited, PhD
    Department of Orthopedic Surgery
    Brigham & Women’s Hospital
    Assistant Professor, Harvard Medical School

 

GUEST:

  • Sean Fair

 

Andreas H. Gomoll, MD
Department of Orthopedic Surgery, BWH
Associate Professor of Orthopedic Surgery, Harvard Medical School

Dr. Gomoll is an Associate Professor of Orthopedic Surgery at Harvard Medical School and member of the Department of Orthopedic Surgery at Brigham and Women’s Hospital, Boston. He is co-director of the BWH Center for Regenerative Medicine, and Director of the Orthopedic Program within that center.

 

Born and raised in Munich, Germany, he received his medical degree from Ludwig-Maximilians-University Munich, with additional training in Orthopaedic and Trauma Surgery in Cape Town, South Africa, and Oxford, UK. Dr. Gomoll completed a post-doctoral research fellowship at Brigham and Women’s Hospital before joining the Harvard Combined Orthopaedic Residency Program at Brigham and Women’s Hospital and Massachusetts General Hospital.

 

Dr. Gomoll is fellowship-trained in Orthopaedic Sports Medicine (Rush University) and specializes in arthroscopy of the knee and shoulder, as well as ACL reconstruction, osteotomy, meniscus and cartilage transplantation. He has lectured and published extensively on the topic of biologic joint reconstruction through cartilage and meniscus transplantation.

 

His main clinical and research interest lies in emerging technologies for joint preservation, most recently investigating the use of stem cells both in the lab and through randomized clinical trials.

marshall

Mallika Marshall, MD
Health Reporter, WBZ-TV (Boston) & Physician, Massachusetts General Hospital

Dr. Marshall is an Emmy-award winning journalist & physician who serves as the regular Health Reporter at WBZ-TV in Boston. Dr. Marshall serves on staff at Harvard Medical School & practices at the MGH Chelsea Urgent Care Clinic & MGH Revere Health Center. She is currently a Contributing Editor for Harvard Health Publications (HHP). She has nearly 15 years of media experience, including serving as “HealthWatch” Anchor at WBZ-TV News for a decade. She was also the Medical Contributor on Katie Couric’s daytime talk show “Katie”, for New England Cable News (NECN) & as the Medical Director for Everyday Health. She has served as the host of “Dr. Mallika Marshall,” a nationally syndicated health news reports series. She was also an Associate Editor of the Harvard Medical School Family Health Guide & a Contributing Editor for InteliHealth. She graduated from Harvard College and has a MD from the University of California, San Francisco (UCSF) School of Medicine.

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Gloria Matthews, DVM, Ph.D.
Chief Medical Officer, Histogenics

Dr. Matthews joined Histogenics in 2015, and has more than 25 years of experience in research and development, clinical operations and technical Prior to Histogenics, Dr. Matthews most recently served as Senior Director and Global Head of Bone and Joint Disease Research and Development at Genzyme, a Sanofi company. During her tenure at Genzyme, Dr. Matthews was involved in clinical and preclinical development and/or post-market support of cell, gene, growth factor, small molecule, and biomaterial based products in the orthopedic and rheumatologic space, including Carticel®, MACI®, Synvisc®, Synvisc One®, and an early clinical development stage Trk inhibitor for osteoarthritis. Her active research areas include cell and molecular biology of osteoarthritis and cartilage repair as well as orthopedic imaging. Dr. Matthews sits on the Board of Directors for the Orthopaedic Research Society for which she chairs the Executive Finance Committee as Treasurer. She chairs the Musculoskeletal Committee of the American Society for Gene and Cell Therapy and also serves on the NIH SBIR Scientific Review Group/Grant Review Committee (study section), the Strategic Alliance Committee of the Osteoarthritis Research Society International, the fNIH Osteoarthritis Biomarkers Working Group, and as a reviewer for the Osteoarthritis Initiative Bioresource Allocation Committee. Dr. Matthews has also established several high-profile collaborations in medicine, academia and industry, and is a published inventor and researcher. She received both her DVM and Ph.D. from Cornell University and became board certified by the American College of Veterinary Surgeons following an equine surgery and sports medicine residency at Tufts University.

 

whited

Jessica L. Whited, PhD
Department of Orthopedic Surgery
Brigham & Women’s Hospital
Assistant Professor, Harvard Medical School

Jessica Whited is an Assistant Professor at Harvard Medical School and the Department of Orthopedic Surgery at Brigham & Women’s Hospital.  She is also a principal faculty member at the Harvard Stem Cell Institute, team member of the Allen Discovery Center at Tufts University, and a 2015 NIH New Innovator Awardee.  Jessica holds a BA in Philosophy and a BS in Biological Sciences from the University of Missouri.  She earned her PhD at MIT, where she studied neuronal architecture in Paul Garrity’s lab.  As a postdoctoral fellow in Cliff Tabin’s lab in the Department of Genetics at Harvard Medical School, Jessica focused on limb regeneration in axolotl salamanders, building more powerful tools for using this system to understand regeneration and establishing a breeding colony of axolotls.  Jessica’s laboratory is focused on understanding how these master regenerators activate the regenerative process and recruit and nourish progenitor cells for the new limb.  The goal is to elucidate the biological mechanisms of successful total limb regeneration so that these insights can be applied to regenerative medicine approaches in the future.

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