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Join discussion leaders Shan Siddiqi, MD (BWH) and Nolan Williams, MD (Stanford) as they engage leading experts from around the world on important topics facing the rapidly emerging field of brain stimulation. Through a series of presentations and discussions, this summit will establish a network of key opinion leaders to yield consensus on specific debates and build an intellectual framework to allow this transformative subspecialty to launch and grow.
Host Institution
Brigham & Women’s Hospital, Boston, MA
Venue
Louis Bornstein Family Amphitheater
Brigham and Women’s Hospital
45 Francis Street
Boston, MA
Discussion Leaders
Shan Siddiqi, MD, Brigham & Women’s Hospital, Harvard Medical School
Nolan Williams, MD, Stanford University School of Medicine
Goals
We aim for this summit to:
- Establish an intellectual framework along which this subspecialty can launch and grow.
- Create a network of experts that can guide the subspecialty forward as it evolves.
- Yield a consensus statement on specific debates in this field (see below)
AGENDA
STATE OF SCIENCE at Bornstein Amphitheater. 10-minute lectures from attendees. Open to all.
| 12:00 – 1:00 |
Stimulating Brain Circuits from Different Vantage PointsRecent data suggest that TMS, DBS, and lesions can treat the same symptom by modulating different parts of the same brain circuit. However, different tools are used by different specialists with minimal cross-talk. There may be ways for these tools to complement each other; for instance, TMS may be used to noninvasively probe a circuit to identify the right DBS/FUS targets and the right candidate patients before surgery. In this session, speakers will present ideas for using these techniques to complement one another. |
John Rolston Darin Dougherty Nick Trapp Binith Cheeran Martijn Figee Shan Siddiqi |
| 1:00 – 2:00 |
Complementary, Competing, and Converging ToolsThere are different approaches to identifying treatment targets and parameters beyond those that are currently in use. Some of these approaches are complementary and others are competing, but in many cases these different approaches may converge on a common answer. |
Nolan Williams Michael Sugrue – neurosurgeon Mark Eldaief – neurologist/cognitive Desmond Oathes – clinical psychologist Damiaan Denys – psychiatrist/interventional Noreen Bukhari – neurologist/movement |
| 2:00 – 2:30 |
Break |
|
| 2:30 – 3:30 |
Exploring the Parameter Space and Monitoring OutcomesThere are very few brain stimulation protocols that are currently in clinical practice, and they are often oversimplified as “excitatory” versus “inhibitory.” Several components can be further optimized, such as treatment parameters (e.g. frequency, intensity), state dependence, and synergistic pharmacotherapy. There are emerging data for how each of these components may be optimized and their outcomes may be monitored. |
Alik Widge -psychiatrist/interventional Joshua Brown – psychiatrist/neurologist Andrew Leuchter – psychiatrist/TMS Moushin Shafi – neurologist/epilepsy Conor Liston – psychiatrist/basic science Alex McGirr – psychiatrist/TMS |
| 3:30 – 4:30 |
Clinical Standards and Off-label TreatmentMany clinicians are using unorthodox brain stimulation protocols. Some of these protocols are designed to maximize revenue rather than maximizing risk-benefit to the patient. On the other hand, off-label protocols may be appropriate when there is early-stage evidence that the benefits outweigh the risks and the patient has not responded to conventional treatment. There are no clear guidelines for what constitutes an acceptable amount of evidence for applying off-label treatment. |
Brian Kopell – neurosurgeon Leo Chen – psychiatrist/TMS Mohammed Ahmed – neuropsychiatrist David Carreon – psychiatrist/TMS Rebecca Allen – neuropsychiatrist Jonathan Downar – psychiatrist/TMS |
| 4:30 – 5:00 |
Break |
|
| 5:00 – 6:00 |
Other TopicsAdditional topics that do not fall into the above categories, but have a high probability of translating to brain stimulation clinical practice in the near future. |
Volker Coenen – neurosurgeon Scott Aaronson – psychiatrist/interventional Catherine Chu – neurologist/child Colleen Hanlon – clinical neuroscientist Noah Philip – psychiatrist/interventional Nicole Peterson – clinical neuroscientist |
DIRECTIONS
Louis Bornstein Family Amphitheater
Enter 15 Francis Street (Peter Bent Brigham Building)
Take a left and walk down the Pike (2nd floor)
Bornstein is between Elevator H and G on the Pike, right side.
From 75 Francis St – Main Lobby
Take the escalator up to the second floor and turn right.
Walk past the gift shop and through the Tower elevator bank to enter the Pike
Bornstein is after Elevator H, on the left.
From 45 Francis Street
Enter through the 45 Francis street entrance, head straight towards The Pike, take a left and Bornstein Family Amphitheater will be on your right between Elevator H and G.
