Calum MacRae, MD, PhD, is Professor of Medicine at Harvard Medical School, an Associate Member at the Broad Institute of Harvard and MIT and a Principal Faculty Member at the Harvard Stem Cell Institute. He is the Director of the One Brave Idea, a program to transform translational biomedicine that is funded jointly by the American Heart Association, Verily Life Sciences and AstraZeneca with pillar support from Quest Diagnostics and the principal investigator of the Apple Heart & Movement study. He directs an NIH-funded basic science group and has focused on systematic approaches to the discovery, modeling and reversal of human disease mechanisms and the role of disruptive innovation in refashioning the clinical-translational interface. He is Co-Director of the Genomic Medicine Program at Brigham and Women’s Hospital and a clinical lead in the Harvard Undiagnosed Diseases Center.