I am a pulmonologist and genetic epidemiologist. I am the Chief of the Channing Division of Network Medicine at Brigham and Women’s Hospital, where we are using network science approaches to analyze genetics, Omics, and phenotypic data in complex diseases. I am the Principal Investigator of multiple studies of COPD genetics, including an extended pedigree study of severe, early-onset COPD (Boston Early-Onset COPD Study); I am also one of two national Principal Investigators of the COPDGene Study. My recent work has focused on identifying functional genetic variants influencing COPD susceptibility; integrating imaging, clinical, genetics, and Omics data to identify COPD subtypes; and defining networks of interacting biological factors in COPD pathogenesis. I am the co-director of the Channing Division of Network Medicine T32 training program, and I have mentored 35 post-doctoral fellows.