Research, Discovery & Innovation

Thoracic Surgery at the Brigham

The third video in our Discovering Brigham series focuses on Thoracic Surgery. Dr. Robert Higgins, President of Brigham and Women's Hospital, sits down with special guests Dr. Raphael Bueno, Chief, Division of Thoracic and Cardiac Surgery, Dr. Blair Marshall, Associate Professor of Surgery and Dr. Paula Ugalde, Associate Surgeon to explore thoracic surgery related research.

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Discover Brigham

About Us

Organized by the Brigham Research Institute since 2012, Discover Brigham showcases cutting-edge science, features our exemplary investigators, and allows research to shine bright on this exciting and much anticipated day each year.

The projects, ideas, and innovations at this annual event bring to life current and diverse topics that resonate with individuals around the world.

This year, a new video series invites the public to learn about the impact of research, discovery and innovation at the Brigham.

Thank You for Attending!

20221101, Tuesday, November 1, 2022, Boston, MA, USA, Brigham Health, Brigham and Women's Hospital, Brigham Research Institute held their annual Discover Brigham campus-wide research day on Tuesday, November 1, 2022.

( 2022 © lightchaser photography )

Discovering Brigham with Dr. Robert Higgins

In Discovering Brigham, Brigham and Women’s Hospital President Dr. Robert S.D. Higgins and leaders from across the Brigham research community engage in conversations about research projects and discoveries that are leading to more equitable, cutting-edge care for all patients.

The video series will highlight various high priority areas through a health equity lens and will end with a poster session in November 2022.

Viewers can expect to learn more about how equity and the urgent needs of patients drive research, discovery and innovation at the Brigham.

Neuroscience

To find out more about the innovative work being done at the Brigham, watch our Discovering Brigham video with special guests Dr. Tracy Batchelor, Chair, Department of Neurology and Dr. Humsa Venkatesh, Assistant Professor of Neurology as they explore neurology related research.

Video Leads

Haley Bridger
Chenzhe Cao
Alexandra Gallant
Chelsea Nickerson
Victoria Roberts
Sara Yohannes

Special Thanks

Dr. Tracy Batchelor, Chair, Department of Neurology

Dr. Robert S.D. Higgins, President, Brigham and Women’s Hospital

Dr. Humsa Venkatesh, Assistant Professor of Neurology and the Venkatesh Laboratory

Supplemental Materials

Alzheimer’s Disease

Articles:
- An Ounce of Prevention: Davis Gift Opens Up New Avenues for Alzheimer’s Research

- Blood Test for Alzheimer’s Disease Predicts Future Cognitive Decline in Healthy People

- Potential Link Found Between Alzheimer’s Disease and Common Brain Disease that Mimics its Symptoms

Awards:
- Look Who’s Talking: ‘Shark Tank’ Award Winners– 2021 Shark Tank Award Winner, Tracy Young-Pearse, PhD

News Articles:
- Alzheimer’s vaccine nasal spray trials underway at Boston’s Brigham and Women’s Hospital

- Brigham and Women’s Hospital hopes to recruit at-risk residents for global Alzheimer’s study

Press Releases:
- To Treat Alzheimer’s and Other Disorders, a Detour Through the Nose

Projects:
- Tracy Young-Pearse, PhD: The contribution of chromosome 21 genes to Alzheimer’s disease risk in Down syndrome

Research Briefs:
- Blood Test for Alzheimer’s Disease Predicts Future Cognitive Decline in Healthy People

- Brigham and Women’s Hospital Launches Clinical Trial of Nasal Vaccine for Alzheimer’s Disease

- Commentary: The Emergence of Alzheimer’s Disease Treatments

- New Brain Model Provides Patient-Specific Alzheimer’s Insights, Predictions of Cognitive Decline

- Potential Link Found Between Alzheimer’s Disease and Common Brain Disease that Mimics its Symptoms

- Subconscious Changes in Movement May Predict Alzheimer’s Disease

Dementia

Research Briefs:
- Ceramides Predict Vascular Brain Injury and Dementia

- New Biomarker for Dementia Improves Risk Prediction

Projects:
- Patrizia Vannini, PhD: working with the Brigham Digital Innovation Hub (iHub) and the Mass Digital Health sandbox program in collaboration with Dear Meme on a digital/non-pharmacological product that would help support caregivers of patients with dementia.

Glioma/Glioblastoma

Articles:
- Epigenetic Study Provides New Insights into the Origins of Glioma

- Two Brigham Scientists Honored for Their Work on Gene & Cell Therapies

Projects:

- Sean Lawler, PhD: Development of brainpenetrating and tumorspecific fluorinated peptides as glioblastoma therapeutics

Multiple Sclerosis (MS)

Articles:
- Researchers Pursue ‘Hidden Pathology’ to Explain Fatigue in Multiple Sclerosis

Research Briefs:
- Case Series: Teriflunomide Therapy in COVID-19 Patients with MS

- New Imaging Molecule Captures Brain Changes Tied to Progressive Multiple Sclerosis

- Researchers Pursue ‘Hidden Pathology’ to Explain Fatigue in Multiple Sclerosis

Neurooncology

Articles:
- Developing Targeted Therapies for Children and Adults with Brain Tumors

Projects:
- Alexander Lin, PhD: pitched at a recent opioid Shark Tank event on fMRI glutamate for pain, a non-invasive neuro-metabolite quantification of pain-relief in cancer patients

Publications:
- Electrical and synaptic integration of glioma into neural circuits

- Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma

- The neural regulation of cancer

Parkinson’s Disease

Articles:
- ASAP Initiative’s $9 million gift elevates Parkinson’s research

- Discovery of Genetic Drivers Linked to Progression in Parkinson’s Disease

- The Parkinson’s Puzzle: Piecing Together a More Personalized Approach

Projects:
- Saranna Fanning, PhD: Evaluating lipases as drug targets for alpha-synuclein toxicity in Parkinson’s disease

Research Briefs:
- Discovery of Genetic Drivers Linked to Progression in Parkinson’s Disease

Stroke

Research Briefs:

Study Finds Potential Causality Between Blood Clot Factors and Migraine with Aura

The Stroke Care Paradox: Close-Knit Social Networks Increase Delays in Hospital Arrival

Cardiovascular Medicine

To find out more about the innovative work being done at the Brigham, watch our Discovering Brigham video with special guests Dr. John Keaney, Chief of Cardiovascular Medicine and Dr. Muthiah Vaduganathan, Instructor in Medicine as they explore cardiovascular related research.

Video Leads

Haley Bridger
Liz Cullen
Alexandra Gallant
Victoria Roberts
Will Tonelli
Sara Yohannes

Special Thanks

Dr. John Keaney, Chief of Cardiovascular Medicine

Dr. Scott Solomon, Director of Clinical Trials Outcomes Center

Dr. Muthiah Vaduganathan, Instructor in Medicine

Supplemental Materials

Cholesterol

Articles:

Heart Disease & Heart Failure

Articles:

A Biomarker-Based Score for Risk of Hospitalization for Heart Failure in Patients With Diabetes

News Articles:

Brigham and Women’s Researchers Say Diabetes Drug Helps Reduce Heart Failure

Press Releases:

Study finds worse outcomes for heart attack survivors living in disadvantaged neighborhoods

Death Rate Dramatically Less for Young Heart Attack Survivors Who Quit Smoking

Research Briefs:
- What Happens to Young Adults After a First Heart Attack?

General Cardiology

Articles:

Percutaneous coronary intervention with drug-eluting stents versus coronary artery bypass grafting in left main coronary artery disease: an individual patient data meta-analysis

News Articles:

Hypertensive pregnancy disorders linked to future cardiac events

Press Releases:

Highly Detailed Map of the Human Heart Could Guide Personalized Heart Treatments

Research Briefs:

Meta-Analysis Finds that Omega-3 Fatty Acids Improved Cardiovascular Outcomes

Study Finds Changes in Wealth Tied to Changes in Cardiovascular Health

Thoracic Surgery

To find out more about the innovative work being done at the Brigham, watch our Discovering Brigham video with special guests Dr. Raphael Bueno, Chief, Division of Thoracic and Cardiac Surgery, Dr. Blair Marshall, Associate Professor of Surgery, Thoracic Surgery, and Dr. Paula Ugalde, Associate Surgeon, Thoracic Surgery as they explore thoracic surgery related research.

Video Leads

Haley Bridger
Alexandra Gallant
Tina Gelsomino
Kelsey Moum
Victoria Roberts
Anu Swaminathan
Sara Yohannes

Special Thanks

Dr. Raphael Bueno, Chief, Division of Thoracic and Cardiac Surgery

Dr. Blair Marshall, Associate Professor of Surgery, Thoracic Surgery

Dr. Paula Ugalde, Associate Surgeon, Thoracic Surgery

Supplemental Materials

Lung Cancer

Press Releases:

Resource:
- Women’s Lung Cancer Program

Occupational and Environmental Diseases

Research Brief:

Video:
- Chronic Obstructive Pulmonary Disease (COPD): Symptoms, History, and More | Mass General Brigham

Pulmonary Vascular Disease

Press Release:

- Meeting an Unmet Need: Surgical Implant that Grows with a Child

Thoracic Surgery

Article

- After a Surprise Diagnosis, Fateful Elevator Ride and Unexpected Connection, Brigham Nurse Becomes First in U.S. to Receive Experimental Surgery

Presented By

Brigham Research Institute
Office for Strategic Communications

In Partnership With

Brigham Office of the President
Brigham Care Redesign Incubator Start Up Program
Brigham Digital Innovation Hub
Brigham Research Administration
Brigham Research Education
Center for Diversity and Inclusion
Office for Research Careers

Additional Support By

Brigham Development Office
MGB Marketing Office

News

Discovering Brigham with Dr. Robert Higgins

August 19, 2022

In a new video series, Discovering Brigham, Brigham and Women’s Hospital President Robert S.D. Higgins, MD, MSHA,

Brigham and Women’s Hospital is testing a nasal vaccine for Alzheimer’s disease

November 16, 2021

Brigham and Women’s Hospital is in the early stages of testing a new nasal vaccine

Do you work at the Brigham? Having trouble with something and not sure who to ask?

Research, Discovery & Innovation

Discover Brigham

About Us

Thank You for Attending!

Discovering Brigham with Dr. Robert Higgins

Neuroscience​

Video Leads

Special Thanks

Supplemental Materials

Cardiovascular Medicine

Video Leads

Special Thanks

Supplemental Materials

Thoracic Surgery

Video Leads

Special Thanks

Supplemental Materials

Presented By

In Partnership With

Additional Support By

News

Neuroscience